Abstract:A perfect mine ventilation system is the key to effectively prevent poisoning and asphyxiation accidents in non-coal mines.Taking the main-auxiliary combined ventilation system of a super-large iron mine as the research object, this paper tests and analyzes the influence of mining methods, the number of middle sections and other mining conditions on the mine ventilation effect. The mine ventilation three-dimensional simulation system software is applied to optimize the mine ventilation system from the aspects of ventilation network, ventilation power, ventilation structure and so on. The results show that the total intake air volume of the mine is increased by about 92 m3/s by optimizing the auxiliary fan setting, the airflow path of the working area and the application of new ventilation structures, which can meet the demand of 670.0 m3/s in the production scale of 5 million t/a. The air volume distribution of the east and west return air shafts is optimized from 1∶1.82 to 1∶1.35, which tends to be balanced, and the flexibility of air flow regulation is enhanced, so as to realize the orderly flow of air flow with double middle and multiple layers working at the same time, which has important application significance for timely removing the dirty air generated in the process of operation.