Abstract:High-entropy alloys (HEAs), consisting of five or more than five elements in near equimolar ratios, have attracted an increasing attention recently. The unique design concept introduces many unusual properties to HEAs, which cannot be achieved by traditional alloy design based on one dominate element. Due to the positive mixing enthalpies with other elements in HEAs, Cu element normally segregates and forms Cu-rich face-centered cubic (fcc) structure in Cu-contained HEAs. This paper briefly reviewed the effect of alloying element, preparation method on the microstructure evolution of Cu-contained HEAs as well as the thermal stability of Cu-contained HEAs. For example, the addition of Al would change the structure of CoCrCuFeNi alloy from fcc single phase to fcc+bcc dual phases. While in AlCoCrCuNi alloy, multi-phase would transfer to single phase with the increase of Ni content. AlCoCuFeNi and AlCoCrCuFeNi alloys prepared by selective laser melting and splat quenching were single phase structure which is due to the high cooling rate inhibiting the diffusion of atoms. The change of microstructure could also affect the mechanical properties. Thus, the effects of alloying element, processing method and temperature on the mechanical property of Cu-contained HEAs were also discussed. For instance, the strength of HEAs could be approved by adding V into the alloy or preparing alloys with additive manufacturing methods such as selective laser melting and laser powder bed fusion.